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Enzymatically-Active RNA-Dependent RNA Polymerase From a Human Norovirus (Calicivirus)

20:00 EDT 31 May 2008 | NIH

The noroviruses (formerly known as “Norwalk-like viruses”) are associated with gastroenteritis outbreaks, affecting large numbers of individuals each year. Emerging data are supporting their increasing recognition as important agents of diarrhea-related morbidity and mortality. The frequency with which noroviruses are associated with gastroenteritis as “food and water-borne pathogens” has led to the inclusion of caliciviruses as Category B Bioterrorism Agents/Diseases. Because the noroviruses cannot be propagated by any means in the laboratory, an important strategy in their study is to development of molecular biology-based tools and replication systems. This invention reports the isolation of the first recombinant, enzymatically-active proteinase and RNA dependent RNA polymerase (RdRp) complex for a human norovirus. This enzyme should facilitate studies aimed at developing therapeutic drugs for norovirus disease.

IC: 
NIAID
NIH Ref. No.: 
E-283-2003-0
Provider Technology ID: 
908
Updated On: 
May 16, 2018
Date Published: 
Sunday, June 1, 2008
Provider Classifications: 
Publications: 
Patent Authority: 
EIR
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NIAID
NIAID
NIAID
NIAID
Inventor Lab URL: 
https://irp.nih.gov/pi/kim-green
LPM FIrst Name: 
Peter
LPM Last Name: 
Soukas
LPM Address: 
5601 Fishers Lane, Suite 6D (MSC 9804)
LPM City: 
Rockville
LPM Zip: 
20892-9804
Inv Is lead: 
LPM State: 
MD
LPM Phone: 
301-496-2644
LPM Suffix: 
J.D.
LPM Organization: 
NIH Office of Technology Transfer
LPM Fax: 
240-627-3117
DTDT Classification: 
Infectious Diseases
Diagnostics
Non-AIDS (only)
Therapeutics
Non-AIDS (only)
Vaccines
Non-AIDS (only)
Research Materials
DTDT Description: 
Infectious Diseases
Infectious Diseases - Diagnostics
Infectious Diseases - Diagnostics - Viral: Non-AIDS
Infectious Diseases - Therapeutics
Infectious Diseases - Therapeutics - Anti-virals: Non-AIDS
Infectious Diseases - Vaccines
Infectious Diseases - Vaccines - Viral: Non-AIDS
Infectious Diseases - Research Materials
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/11152494
Publication Caption: 
PMID 11152494
Publication Title: 

Wei L, et al. Proteinase-polymerase precursor as the active form of feline calicivirus RNA-dependent RNA polymerase.

Additional Patents: 
Research Material -- Patent protection is not being pursued for this technology
Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

The Laboratory of Infectious Diseases, NIAID, NIH, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize an active human norovirus proteinase-polymerase enzyme. Please contact Kim Y. Green at kgreen@niaid.nih.gov for more information.

Related Patent Authority: 
EIR
EIR
EIR
Related Invention: 
E-198-2003-0
E-212-2003-0
E-214-2003-0
E Number Only: 
E-283-2003-0
Inventor First Name: 
Kyeong-Ok
Lisbeth Kim
Stanislav
Gael
Inventor Last Name: 
Chang
Green
Sosnovtsev
Belliot

Original Article: Enzymatically-Active RNA-Dependent RNA Polymerase From a Human Norovirus (Calicivirus)

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