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Construction of Recombinant Baculoviruses Carrying the Gene Encoding the Major Capsid Protein, VP1, From Calicivirus Strains (Including Norovirus Strains Toronto, Hawaii, Desert Shield, Snow Mountain, and MD145-12)

20:00 EDT 31 May 2008 | NIH

The noroviruses (known as "Norwalk-like viruses") are associated with an estimated 23,000,000 cases of acute gastroenteritis in the United States each year. Norovirus illness often occurs in outbreaks, affecting large numbers of individuals, illustrated recently by well-publicized reports of gastroenteritis outbreaks on several recreational cruise ships and in settings such as hospitals and schools. Norovirus disease is clearly important in terms of medical costs and missed workdays, and accumulating data support its emerging recognition as important agents of diarrhea-related morbidity.

Because the noroviruses cannot be propagated by any means in the laboratory, an important strategy in their study is the development of molecular biology-based tools. This invention reports the development of recombinant baculoviruses carrying the capsid gene from several caliciviruses associated with human disease. Growth of these baculovirus recombinants in insect cells results in the expression of virus-like particles (VLPs) that are antigenically indistinguishable from the native calicivirus particle. These VLPs can be purified in large quantities for use as diagnostic reagents and potential vaccine candidates.

IC: 
NIAID
NIH Ref. No.: 
E-198-2003-0
Provider Technology ID: 
910
Updated On: 
May 16, 2018
Date Published: 
Sunday, June 1, 2008
Provider Classifications: 
Publications: 
Patent Authority: 
EIR
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NIAID
NIAID
Inventor Lab URL: 
https://irp.nih.gov/pi/kim-green
LPM FIrst Name: 
Peter
LPM Last Name: 
Soukas
LPM Address: 
5601 Fishers Lane, Suite 6D (MSC 9804)
LPM City: 
Rockville
LPM Zip: 
20892-9804
Inv Is lead: 
LPM State: 
MD
LPM Phone: 
301-496-2644
LPM Suffix: 
J.D.
LPM Organization: 
NIH Office of Technology Transfer
LPM Fax: 
240-627-3117
DTDT Classification: 
Infectious Diseases
Diagnostics
Viral
Non-AIDS (only)
Therapeutics
Anti-virals
Non-AIDS (only)
Vaccines
Viral
Non-AIDS (only)
Research Materials
DTDT Description: 
Infectious Diseases
Infectious Diseases - Diagnostics
Infectious Diseases - Diagnostics - Viral
Infectious Diseases - Diagnostics - Viral: Non-AIDS
Infectious Diseases - Therapeutics
Infectious Diseases - Therapeutics - Anti-virals
Infectious Diseases - Therapeutics - Anti-virals: Non-AIDS
Infectious Diseases - Vaccines
Infectious Diseases - Vaccines - Viral
Infectious Diseases - Vaccines - Viral: Non-AIDS
Infectious Diseases - Research Materials
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/11807686
Publication Caption: 
PMID 11807686
Publication Title: 

Green KY, et al. A predominant role for Norwalk-like viruses as agents of epidemic gastroenteritis in Maryland nursing homes for the elderly.

Additional Patents: 
Research Material --Patent protection is not being pursued for this technology
Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

The Laboratory of Infectious Diseases, NIAID, NIH, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize norovirus VLP antigens. Please contact Kim Y. Green at kgreen@niaid.nih.gov for more information.

Related Patent Authority: 
EIR
EIR
EIR
Related Invention: 
E-212-2003-0
E-214-2003-0
E-283-2003-0
E Number Only: 
E-198-2003-0
Inventor First Name: 
Lisbeth Kim
Stanislav
Inventor Last Name: 
Green
Sosnovtsev

Original Article: Construction of Recombinant Baculoviruses Carrying the Gene Encoding the Major Capsid Protein, VP1, From Calicivirus Strains (Including Norovirus Strains Toronto, Hawaii, Desert Shield, Snow Mountain, and MD145-12)

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