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T-Cell-Specific Gfi-1 Knockout Mouse

19:00 EST 24 Jan 2010 | NIH

This is a mouse model available to study T-cell differentiation. Growth factor independent 1 (GFi-1) is a transcriptional repressor that is transiently induced during T-cell activation. This knockout mouse line is a GFi-1[flox/flox] introduced into a mouse Cre controlled by a CD4 promoter, which allows selective removal of GFi-1 exclusively in T-cells. It has thus-far been used to demonstrate that GFi-1 plays a critical role in enhancing Th2 cell expansion and repressing induction of Th17 and CD103+ iTreg cells.

IC: 
NIAID
NIH Ref. No.: 
E-242-2009-0
TAB No: 
TAB-2059
Applications: 
  • Tool for studying T-cell proliferation and differentiation.
Provider Technology ID: 
2059
Updated On: 
May 16, 2018
Date Published: 
Monday, January 25, 2010
Provider Classifications: 
Publications: 
Patent Authority: 
EIR
licensing-contacts field-type-field-collection field-label-above">
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NIAID
NIAID
Inventor Lab URL: 
https://irp.nih.gov/pi/jinfang-zhu
LPM FIrst Name: 
Yogikala
LPM Last Name: 
Prabhu
LPM Address: 
BG 5601FL RM 2G56 MSC 9804 5601 FISHERS LN
LPM City: 
Bethesda
LPM Zip: 
20892-9804
Inv Is lead: 
LPM State: 
MD
LPM Phone: 
301-761-7789
LPM Organization: 
NIH Office of Technology Transfer
DTDT Classification: 
Research Materials - not elsewhere provided for.
Brochure - Animal Model
DTDT Description: 
Research Materials
Animal Model
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/19188499
Publication Caption: 
PMID 19188499
Publication Title: 

Zhu J, et al.

Additional Patents: 
Research Tool -- patent protection is not being pursued for this technology
Collaboration Sought: 
Yes
Institute or Center: 
E Number Only: 
E-242-2009-0
Inventor First Name: 
Jinfang
William
Inventor Last Name: 
Zhu
Paul

Original Article: T-Cell-Specific Gfi-1 Knockout Mouse

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