Advertisement

Topics

Method for Convection Enhanced Delivery of Therapeutic Agents

19:00 EST 31 Oct 2002 | NIH

The invention is a method for monitoring the spatial distribution of therapeutic substances by MRI or CT that have been administered to tissue using convection-enhanced delivery, a technique that is the subject of NIH-owned U.S. Patent No. 5,720,720. In one embodiment, the tracer is a molecule, detectable by MRI or CT, which functions as a surrogate for the motion of the therapeutic agent through the solid tissue. In other particular embodiments, the tracer is the therapeutic agent conjugated to an imaging moiety. The method of this invention uses non-toxic macromolecular MRI contrast agents comprised of chelated Gd(III). In particular, the surrogate tracer used in this invention is a serum albumin conjugated with either a gadolinium chelate of 2-(p-isothiocyanotobenzyl)-6-methyldiethylenetriamine pentaacetic acid or with iopanoic acid. These macromolecular imaging agents have clearance properties that mimic the pharmacokinetic properties of co-administrated drugs, so as to be useful in quantifying the range and dosage level of therapeutic drugs using MR imaging.

IC: 
NINDS
NIH Ref. No.: 
E-202-2002-0
TAB No: 
TAB-653
Provider Technology ID: 
653
Updated On: 
May 18, 2018
Date Published: 
Friday, November 1, 2002
Provider Classifications: 
Patent Application: 
10/528,310
PCT/US03/30155
Publications: 
Patent Authority: 
US
PCT
2016-05-04 00:00:00
2016-05-04 00:00:00
Patent Number: 
7,371,225
Licensing Contacts: 
LPM Address: 
  --
United States
Lead Inventor: 
Inventor IC: 
NINDS
LPM FIrst Name: 
Susan
LPM Last Name: 
Ano
LPM Address: 
31 Center Drive, Bldg 31, Room 8A28B (MSC 2540)
LPM City: 
Bethesda
LPM Zip: 
20892
Inv Is lead: 
LPM State: 
MD
LPM Phone: 
301-435-5515
LPM Suffix: 
Ph.D.
LPM Organization: 
NIH Office of Technology Transfer
DTDT Classification: 
Devices/Instruments; Software; Mfg Technology/Methods; Research Tools & Material
Diagnostics
Methods
DTDT Description: 
Devices/Instrumentation
Devices/Instrumentation - Diagnostics
Devices/Instrumentation - Diagnostics - Imaging: Methods
Pat Filing Date: 
2005-03-17
2003-09-24
Patent Issue Date: 
2008-05-13
Technology Term: 
Collaboration Sought: 
Yes
Institute or Center: 
E Number Only: 
E-202-2002-0
Inventor First Name: 
Edward
Inventor Last Name: 
Oldfield

Original Article: Method for Convection Enhanced Delivery of Therapeutic Agents

NEXT ARTICLE

More From BioPortfolio on "Method for Convection Enhanced Delivery of Therapeutic Agents"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topic

Radiology
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...