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Update on Phase III clinical trials of lanabecestat for Alzheimer's disease

06:00 EDT 12 Jun 2018 | World Pharma News

AstraZenecaAstraZeneca and Eli Lilly and Company (Lilly) are discontinuing the global Phase III clinical trials of lanabecestat, an oral beta secretase cleaving enzyme (BACE) inhibitor, for the treatment of Alzheimer's disease. The decision is based on recommendations by an independent data monitoring committee (IDMC), which concluded that both the AMARANTH trial, in early Alzheimer's disease, and the DAYBREAK-ALZ trial, in mild Alzheimer's disease dementia, were not likely to meet their primary endpoints upon completion and therefore should be stopped for futility.

Original Article: Update on Phase III clinical trials of lanabecestat for Alzheimer's disease

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