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Exosomes Shown to be Involved in Spread of Amyloid Beta in Alzheimer’s

05:05 EDT 14 Jun 2018 | Genetic Engineering News

Researchers report that exosomes appear to play a key role in the spread of Alzheimer's disease in the brain. Long understood that the main task of exosomes was to help the cell get rid of waste products, it’s now known that exosomes can contain both proteins and genetic material, which other cells can absorb, explain the scientists. In a new study (“ Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers ”), published in Acta Neuropathologica, a team at Linköping University says that exosomes can transport toxic aggregates of amyloid beta, thus spreading the disease to new neurons. Aggregated amyloid beta is one of the main findings in the brains of patients with Alzheimer's disease, the other being aggregates of the tau protein. As time passes, they form ever-increasing deposits in the brain, which coincides with the death of nerve cells.  “The gradual deterioration of cognitive functions in Alzheimer’s disease is ...

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