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DermTech, Inc., the global leader in non-invasive molecular dermatology, announced today the publication of two clinical study abstracts at the 2018 International Investigational Dermatology meeting in Orlando, Fl. A real world clinical utility study, “Real-world experience and clinical utility of a non-invasive gene expression test for primary cutaneous melanoma and validation against high risk driver mutations in BRAF, NRAS and the TERT promoter," demonstrated that combining gene expression and mutation analyses enhances the ability to non-invasively detect early melanoma.
The second clinical study “Non-invasive tape sampling reveals a type I interferon RNA signature in cutaneous lupus erythematosus that distinguishes affected from unaffected and healthy volunteer skin,” was conducted at Harvard Medical School and Brigham and Women’s Hospital. Type I interferon genes (IFN-I) are upregulated in skin lesions and blood from patients with cutaneous lupus erythematosus (CLE). This study assessed the feasibility of an adhesive tape device to collect RNA from affected and unaffected skin and its potential to detect gene expression differences between groups. The non-invasive technique demonstrated promise for the diagnosis, stratification and follow up of patients with CLE.
“Both studies demonstrate the potential of our adhesive patch skin sample collection platform to assess gene expression and mutations non-invasively in skin cancer as well as in inflammatory skin conditions,” said Dr. Burkhard Jansen, DermTech’s CMO.
DermTech is the global leader in molecular dermatology, bringing precision medicine to the diagnosis and treatment of skin disease. We market and develop products that facilitate the early detection of skin cancers, assess inflammatory diseases, and customize drug treatments. DermTech analyzes skin biopsy samples collected non-invasively using an adhesive patch rather than a scalpel. Our mission is to transform dermatology by delivering highly accurate and objective information to the clinician to improve care and reduce costs and to pharma partners to support the development of targeted therapeutics. For additional information visit dermtech.com.
Sarah Dion, MBA
VP, Sales and Marketing
Acne Dermatology Eczema Psoriasis Wound Care Dermatology is the medical specialty concerned with the diagnosis and treatment of skin disorders (Oxford Medical Dictionary). As well as studying how the skin works, dermatology covers...
The process of gene expression is used by eukaryotes, prokaryotes, and viruses to generate the macromolecular machinery for life. Steps in the gene expression process may be modulated, including the transcription, RNA splicing, translation, and post-tran...
Melanoma is a highly malignant tumor of melanin-forming cells (melanocytes) There are most commonly found in the skin (resulting from sunlight exposure), but also in the eyes and mucous membranes. Metastasis to other regions of the body is also common....