Methods of Inducing Immune Tolerance Using Immunotoxins

20:00 EDT 31 May 2007 | NIH

The invention concerns immunotoxins and methods of using the immunotoxins for the treatment of rejection response in a patient, including graft-versus-host disease and transplantation of organs, tissues and cells into a host. In a specific embodiment of the invention, the transplant involves pancreatic islet cells. The immunotoxins are targeted via an antibody that is specific to T cells. This allows the specific ablation of resting T cells, resulting in an accentuation of immune tolerizing responses and an increased tolerance to transplants and grafts.

Original Article: Methods of Inducing Immune Tolerance Using Immunotoxins


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