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Thermal Protein Profiling May Offer New Insights on Antibiotic Resistance

06:38 EDT 9 Jul 2018 | Genetic Engineering News

Scientists from the European Molecular Biology Laboratory (EMBL) say they have adapted an existing technique to study the melting behavior of proteins so that it can be used for the study of bacteria. Antibiotic resistance is spreading worldwide so there is a strong need for new technologies to study bacteria, according to the researchers who published their study (“ Thermal proteome profiling in bacteria: probing protein state  in vivo ”)  in  Molecular Systems Biology. “We adapted thermal proteome profiling (TPP) to probe the thermostability of  Escherichia coli  proteins in vivo.  E. coli  had a more thermostable proteome than human cells, with protein thermostability depending on subcellular location—forming a high-to-low gradient from the cell surface to the cytoplasm. While subunits of protein complexes residing in one compartment melted similarly, protein complexes spanning compartments often had their subunits melting in a location-wise manner. Monitoring the  E. coli  meltome and proteome at different growth phases captured changes ...

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