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Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have discovered a new microosmometer that allows for the quantification of minor changes in the swelling properties of different materials (including tissue specimens) using microgram amounts of sample. Varying the vapor pressure in the environmental chamber of the device induces controlled changes in the osmotic pressure of the specimen on the surface of a flat quartz crystal microbalance. Variation in the swelling degree is measured with high sensitivity and reliability by monitoring the change in resonance frequency of the quartz crystal oscillator. The device requires less than one microgram of sample, and possesses an extremely fast response time. The device is well-suited to the study of a wide range of biological, macromolecular, polymeric, gel, or other samples.
Horkay F, et al. Osmotic investigations on cartilage biopolymers and tissue engineered cartilage samples using a new tissue microosmometer.
Horkay F, et al. Measurement of the osmotic properties of thin polymer films and biological tissue samples.
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