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Microosmometer for the Study of a Wide Range of Biological, Macromolecular, Polymeric, Gel, or Other Samples

20:00 EDT 8 Jul 2018 | NIH

Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have discovered a new microosmometer that allows for the quantification of minor changes in the swelling properties of different materials (including tissue specimens) using microgram amounts of sample. Varying the vapor pressure in the environmental chamber of the device induces controlled changes in the osmotic pressure of the specimen on the surface of a flat quartz crystal microbalance. Variation in the swelling degree is measured with high sensitivity and reliability by monitoring the change in resonance frequency of the quartz crystal oscillator. The device requires less than one microgram of sample, and possesses an extremely fast response time. The device is well-suited to the study of a wide range of biological, macromolecular, polymeric, gel, or other samples.

IC: 
(NICHD)
NIH Ref. No.: 
E-280-2002
Advantages: 
  • Requirement of 1 microgram allows probing local osmotic properties of small samples
  • Rapid equilibration permits fast sample analysis
  • Non-destructive evaluation possible 
Applications: 
  • Measuring hydration characteristics in tissue and other samples
  • Measuring hydration isotherms in micro-gram quantities of samples
  • Wide areas of application in material science, polymer science, processing, food packaging, adhesives, paint manufacture, etc.
Development Status: 

Prototype

Updated On: 
Jul 9, 2018
Provider Classifications: 
Date Published: 
Monday, July 9, 2018
Publications: 
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
(NICHD)
(NICHD)
(NICHD)
Inventor Lab URL: 
https://irp.nih.gov/pi/peter-basser
LPM FIrst Name: 
John
LPM Last Name: 
Hewes
Inv Is lead: 
LPM Phone: 
240-276-5515
LPM Suffix: 
Ph.D.
LPM Organization: 
NCI - National Cancer Institute
DTDT Classification: 
Devices
DTDT Description: 
Devices
Pat Filing Date: 
2002-08-07
2003-08-07
Patent Issue Date: 
2008-06-03
Publication Link: 
http://europepmc.org/articles/PMC1913834
https://www.ncbi.nlm.nih.gov/pubmed/?term=15762669
Publication Caption: 
PMCID PMC1913834
PMID 15762669
Publication Title: 

Horkay F, et al. Osmotic investigations on cartilage biopolymers and tissue engineered cartilage samples using a new tissue microosmometer.  

Horkay F, et al. Measurement of the osmotic properties of thin polymer films and biological tissue samples.  

Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Licensing and research collaboration

E Number Only: 
E-280-2002
Inventor First Name: 
Ferenc
Peter
Adam
Inventor Last Name: 
Horkay
Basser
Berman

Original Article: Microosmometer for the Study of a Wide Range of Biological, Macromolecular, Polymeric, Gel, or Other Samples

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