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Establishment of Induced Pluripotent Stem Cells (iPSC) from the Thirteen-lined Ground Squirrel

20:00 EDT 19 Jun 2018 | NIH

The limited choice in cell types available for in vitro studies has become an obstacle in hibernation research. 

Researchers at the NAtional Eye Institute for the first time have successfully established iPSC line(s) from a mammalian hibernator, which can be potentially used to generate various cell types and tissue models for in-depth mechanistic studies of hibernation and coldness tolerance in vitro. 

Hibernation-specific features make this line a unique platform and valuable tool for inspiring novel pharmacological strategies. For example, they can be used to bestow cold adaptability to target cells and organs derived from non-hibernating mammals, as well as translating cold-adaptive strategies into humans in clinical applications, such as neural injury or other diseases that involve cold intolerance.

Compared with human iPSC-derived neurons, GS iPSC-derived neurons are not susceptible to cold stress treatment.

IC: 
NEI
NIH Ref. No.: 
E-059-2017
Advantages: 
  • The first iPSC line established from small hibernators like ground squirrel
  • Potential in generating various cell types and tissue models for in-depth mechanistic studies of hibernation and coldness tolerance in vitro
  • Unique benefits in studying hibernation mechanism and cold-adaptive strategies 
Applications: 
  • Research tool for studying hibernation and cold adaptability and disease modeling
  • Drug screening platform for neuronal injuries or other diseases
Development Status: 

Pre-clinical (in vivo)

Updated On: 
Jun 26, 2018
Date Published: 
Wednesday, June 20, 2018
Provider Classifications: 
Publications: 
patent field-type-field-collection field-label-hidden">
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NEI
Inventor Lab URL: 
https://irp.nih.gov/pi/wei-li
LPM FIrst Name: 
John
LPM Last Name: 
Hewes
Inv Is lead: 
LPM Phone: 
240-276-5515
LPM Suffix: 
Ph.D.
LPM Organization: 
NCI - National Cancer Institute
DTDT Classification: 
Research Materials
DTDT Description: 
Research Materials
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/29576452
Publication Caption: 
PMID: 29576452
Publication Title: 

J. Ou et al. iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications  

Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Licensing only

E Number Only: 
E-059-2017
Inventor First Name: 
Wei
Inventor Last Name: 
Li

Original Article: Establishment of Induced Pluripotent Stem Cells (iPSC) from the Thirteen-lined Ground Squirrel

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