Advertisement

Topics

Multifunctional RNA Nanoparticles as Cancer and HIV Therapeutics

14:37 EDT 12 Jul 2018 | NIH

The promise of RNA interference based therapeutics is made evident by the recent surge of biotechnological drug companies that pursue such therapies and their progression into human clinical trials. The present invention discloses novel RNA  and RNA/DNA nanoparticles including  multiple siRNAs, RNA aptamers, fluorescent dyes, and proteins. These RNA nanoparticles are useful for various nanotechnological applications. This technology has a higher detection sensitivity and higher silencing efficiencies of targeted genes than conventional siRNAs.  This technology has significant therapeutic potential against multiple disease types, including, cancer and viral infections.  Xxenograft mouse models indicated uptake of the nanoparticles, and six different HIV targets were validated with cell cultures.

IC: 
NCI
NIH Ref. No.: 
E-765-2013
Advantages: 
  • Potential for higher sensitivity, higher efficiency, low cytotoxicity, multiple functionality, multiple targets, and controlled activation
Applications: 
  • Treatment for cancer and HIV
Development Status: 

Pre-clinical (in vivo)

Updated On: 
Jun 18, 2018
Provider Classifications: 
Publications: 
Patent Application: 
15/022,530
Patent Authority: 
US National Stage
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NCI
Inventor Lab URL: 
https://irp.nih.gov/pi/bruce-shapiro
LPM FIrst Name: 
John
LPM Last Name: 
Hewes
Inv Is lead: 
LPM Phone: 
240-276-5515
LPM Suffix: 
Ph.D.
LPM Organization: 
NCI - National Cancer Institute
DTDT Classification: 
Therapeutics
DTDT Description: 
Therapeutics
Pat Filing Date: 
2016-03-16
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/25521794
Publication Caption: 
PMID: 25521794
Publication Title: 

Kirill A. Afonin, et al. "Triggering of RNA Interference with RNA-RNA, RNA-DNA, and DNA- RNA Nanoparticles" 

Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Licensing and research collaboration

Related Invention: 
E-039-2012
E-156-2014
E Number Only: 
E-765-2013
Inventor First Name: 
Bruce
Kirill
Angelica
Mathias
Inventor Last Name: 
Shapiro
Afonin
Martins
Viard

Original Article: Multifunctional RNA Nanoparticles as Cancer and HIV Therapeutics

NEXT ARTICLE

More From BioPortfolio on "Multifunctional RNA Nanoparticles as Cancer and HIV Therapeutics"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Biotechnology
Antibodies Antisense Assays Biochips Bioinformatics Biological Therapy Biomarkers Biomaterials Bioscience Cell Culture Cloning Cytokine Diagnostics Dna Extraction Dna Sequencing Dna Transform...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...