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The technology available is computer software for the automated generation of density maps of macromolecular structures from a series of 2D digital micrographs of frozen hydrated specimens collected using an electron microscope equipped with an ultra-cooled computerized stage. A series of images of biological specimens collected at different tilt angles relative to the electron beam are aligned to compensate for mechanical errors of the stage and combined to obtain 3D images (tomograms). Sub-volumes containing a single macromolecular complex can be extracted from the 3D image of a protein solution, or from a suspension of viruses or cells. The individual sub-volumes of identical structures are aligned and averaged together to generate a density map of the macromolecular complex of interest.
F. Amat et al. Markov random field based automatic image alignment for electron tomography.
A. Bartesaghi et al. An energy-based three-dimensional segmentation approach for the quantitative interpretation of electron tomograms.
Licensing and research collaboration
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Collaborations in biotechnology
Commercial and academic collaborations are used throughout the biotechnology and pharmaceutical sector to enhance research and product development. Collaborations can take the form of research and evaluation agreements, licensing, partnerships etc. ...
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...