Advertisement

Topics

Treatment of Prostate Cancer using Anti-androgen Small Molecules

14:37 EDT 12 Jul 2018 | NIH

Castrate-resistant prostate cancer (CRPC) is characterized by androgen-independent cancer cells that have adapted to the depletion of hormones and continue to grow. Abnormal androgen receptor signaling is known to drive advanced castrate-resistant prostate cancer. The small molecule compounds of this invention are antiandrogens that target androgen receptor signaling in both androgen-independent and androgen-sensitive androgen receptor activity, and androgen receptors that are resistant to the current antiandrogens available.  Unlike the currently available antiandrogens, the new small molecules induce androgen receptor degradation and cell death in prostate cancer cells. Further, these compounds and methods can also induce degradation of other steroid hormone receptors demonstrating the possibility of treating a wider range of cancers.

IC: 
NCI
NIH Ref. No.: 
E-015-2011
Advantages: 
  • First small molecule antiandrogen treatment
  • Causes cell death, not just loss of function
  • Potential to treat other cancers through degradation of other steroid hormone receptors
Applications: 
  • Series of steroid receptor compounds that cause cancer cell death
  • Method of using the compounds in cancer treatment
Development Status: 

Discovery (Lead Identification)

Updated On: 
May 30, 2018
Provider Classifications: 
Publications: 
Patent Application: 
61/497,129
Patent Authority: 
U.S.
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NCI
NCI
NCI
NCI
NCI
Inventor Lab URL: 
https://ccr.cancer.gov/developmental-therapeutics-branch/jane-b-neckers
LPM FIrst Name: 
John
LPM Last Name: 
Hewes
Inv Is lead: 
LPM Phone: 
240-276-5515
LPM Suffix: 
Ph.D.
LPM Organization: 
NCI - National Cancer Institute
DTDT Classification: 
Therapeutics
DTDT Description: 
Therapeutics
Pat Filing Date: 
2011-06-15
Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Licensing only

E Number Only: 
E-015-2011
Inventor First Name: 
Jane
Yeong
Sunmin
Vineet
Sanjay
Inventor Last Name: 
Trepel Neckers
Kim
Lee
Kumar
Malhotra

Original Article: Treatment of Prostate Cancer using Anti-androgen Small Molecules

NEXT ARTICLE

More From BioPortfolio on "Treatment of Prostate Cancer using Anti-androgen Small Molecules"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Cancer
  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...

Prostate Cancer
Prostate cancer (cancer de prostata) Prostate cancer (cancer de prostata) is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostat...