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Fully-human Monoclonal Antibodies Against Human EphrinB2 and EphB4

14:37 EDT 12 Jul 2018 | NIH

Ephrin receptor tyrosine kinases and their ephrin ligands have been implicated in cancer pathogenesis. Ephrin receptors and ligands affect tumor growth, invasiveness, angiogenesis, and metastasis. Ephrin signaling activities in cancer are complex and are only now beginning to be uncovered.

Researchers at the National Cancer Institute-Frederick, NIH developed a set of five fully-human monoclonal antibodies against human Ephrin-B2 and Ephrin type-B receptor 4 ("EphB4"). The antibodies were identified by screening a naive human antibody phage display library against Ephrin-B2 and EphB4. These human monoclonal antibodies have high affinity and specificity for Ephrin-B2 and EphB4.

NIH Ref. No.: 
E-331-2008
Advantages: 
  • High affinity and antigen specificity
  • Bind both soluble ectodomains and cell surface-expressed molecules
Applications: 
  • Research reagents for in vitro/in vivo investigation of Ephrin receptor and ligand interactions
  • Targeting reagents for in vivo imaging
  • Research reagents for protein co-crystallization
Development Status: 

Discovery (Lead Identification)

Updated On: 
May 30, 2018
Provider Classifications: 
Publications: 
Licensing Contacts: 
Lead Inventor: 
LPM FIrst Name: 
John
LPM Last Name: 
Hewes
Inv Is lead: 
LPM Phone: 
240-276-5515
LPM Suffix: 
Ph.D.
LPM Organization: 
NCI - National Cancer Institute
DTDT Classification: 
Research Materials
DTDT Description: 
Research Materials
Collaboration Sought: 
Yes
Collaboration Opportunity: 

Licensing only

E Number Only: 
E-331-2008
Inventor First Name: 
Dimiter
Inventor Last Name: 
Dimitrov

Original Article: Fully-human Monoclonal Antibodies Against Human EphrinB2 and EphB4

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