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Transgenic Mouse Model of Human Basal Triple Negative Breast Cancer

14:37 EDT 12 Jul 2018 | NIH

The NCI Laboratory of Cancer Biology and Genetics seeks parties interested in collaborative research to further develop this mouse model of triple-negative breast cancer (TNBC) to study cancer biology and for preclinical testing.  As a Research Tool, patent protection is not being pursued for this technology.

Basal triple-negative breast cancer (TNBC) is a common form of human breast cancer for which there are no specific, targeted therapies, unlike hormone-responsive or Her2+ breast cancers. TNBC has a much worse prognosis than hormone receptor + cancer and is disproportionately high in the African-American population. NIH scientists have created and characterized a transgenic model that is currently an excellent mouse model for TNBC that shares important molecular characteristics of human TNBC making it highly useful for preclinical testing of drugs and novel therapies. This model may provide a valuable means of identifying new drugs and therapies that could be translated to human clinical trials. The mouse model also develops prostate intraepithelial neoplasia and prostate cancer, therefore has also been used for studies of prostate cancer.

IC: 
NCI
NIH Ref. No.: 
E-191-2010
Advantages: 
  • Shares important molecular characteristics of human TNBC making it highly useful for preclinical testing of drugs and novel therapies
Applications: 
  • Mouse model for pre-clinical validations
Development Status: 

Pre-clinical (in vivo)

Updated On: 
May 30, 2018
Provider Classifications: 
Publications: 
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NCI
LPM FIrst Name: 
John
LPM Last Name: 
Hewes
Inv Is lead: 
LPM Phone: 
240-276-5515
LPM Suffix: 
Ph.D.
LPM Organization: 
NCI - National Cancer Institute
DTDT Classification: 
Research Materials
DTDT Description: 
Research Materials
Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Licensing only

E Number Only: 
E-191-2010
Inventor First Name: 
Jeffrey
Inventor Last Name: 
Green

Original Article: Transgenic Mouse Model of Human Basal Triple Negative Breast Cancer

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