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Systems and Devices for Training and Imaging an Awake Test Animal

20:00 EDT 30 Apr 2017 | NIH

Typical MRI imaging sessions can last over 45 minutes and depend on the subject remaining still during the procedure for accurate imaging. In particular, animals being imaged, such as rodents (rats) in an awakened state, are not readily compliant with the restricted movement required when being imaged. Current techniques for imaging awake animals focus on training them with full body restraints and head fixation using a bite bar and/or ear bars. Physically restraining the animal can induce stress, thereby resulting in unavoidable movement of the stressed animal and likely inaccurate imaging.

Researchers at the National Institute on Drug Abuse (NIDA) developed an invention that permits prolonged imaging of awake rodents (no anesthesia needed) with minimal confinement and reduces stress. The invention is an apparatus and training system for rodents to maintain its head substantially motionless during an imaging (e.g. MRI) procedure. The system includes a frame defining an enclosure for enclosing an animal therein during the imaging procedure. The system has a head post attached to the head of the animal and a treadmill having a plurality of rollers that the animal walks on such that one or more of the wheels rotate when the animal is in walking motion and stop rotating when the animal is substantially motionless. This arrangement trains the animal to remain substantially motionless when disposed within an imaging apparatus for more accurate imaging and fewer artifacts.

IC: 
NIDA
NIH Ref. No.: 
E-043-2015
Advantages: 
  • Imaging while an animal is awake (no anesthesia needed)
  • Less stress-inducing imaging and minimal confinement
Applications: 
  • Imaging awake rodents
  • Imaging pharmacological agent distribution in rodents
  • Monitoring the therapeutic effects of a pharmacological agent
Development Status: 

Prototype

Updated On: 
May 30, 2018
Provider Classifications: 
Date Published: 
Monday, May 1, 2017
Publications: 
Patent Application: 
14/589,725
Patent Authority: 
US
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NIDA
NIDA
Inventor Lab URL: 
https://irp.drugabuse.gov/staff-members/hanbing-lu-ph-d/
https://irp.drugabuse.gov/Stein.php
https://irp.drugabuse.gov/staff-members/yihong-yang-ph-d/
LPM FIrst Name: 
John
LPM Last Name: 
Hewes
Inv Is lead: 
LPM Phone: 
240-276-5515
LPM Suffix: 
Ph.D.
LPM Organization: 
NCI - National Cancer Institute
DTDT Classification: 
Devices
DTDT Description: 
Devices
Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Licensing only

E Number Only: 
E-043-2015
Inventor First Name: 
Hanbing
Elliot
Yihong
Inventor Last Name: 
Lu
Stein
Yang

Original Article: Systems and Devices for Training and Imaging an Awake Test Animal

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