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New Method Developed to Help Determine Effectiveness of Cancer Drugs

03:40 EDT 13 Jul 2018 | Genetic Engineering News

Researchers report the development of a technique that allows them to measure how well cancer drugs reach their targets inside the body. It shows individual cancer cells in a tumor in real time, revealing which cells interact with the drug and which cells the drug fails to reach, according to the scientists. In the future, the findings (“ Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy ”), published in  Nature Communications , could help clinicians decide the best course and delivery of treatment for cancer patients, note the researchers. “We present an approach to quantify drug–target engagement using in vivo fluorescence endomicroscopy, validated with in vitro measurements. Doxorubicin binding to chromatin changes the fluorescence lifetime of histone-GFP fusions that we measure in vivo at single-cell resolution using a confocal laparo/endomicroscope. We measure both intra- and inter-tumor heterogeneity in doxorubicin chromatin engagement in a ...

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