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European researchers have discovered how a gene that has previously been implicated in cancer plays a key role in certain regions of the brain in the control of cocaine addiction in mice. Studies headed by a team at the Université Libre de Bruxelles (ULB) in Belgium showed that animals lacking the melanoma antigen gene (Mage) known as Maged1 were unresponsive to cocaine, and didn’t develop the characteristic behaviours and signs of addiction, such as locomotor sensitization, drug seeking and drug self-administration, which are evident in control animals after repeated drug administration. Studies in which the Maged1 gene was deleted in specific regions of the brain indicated that the development of cocaine sensitization required Maged1 expression in the prefrontal cortex (PFC) and amygdala regions of the brain specifically. “This work identifies Maged1 as a critical molecule in cellular processes and behaviours related to addiction,” write lead scientist Alban de ...
Original Article: Addiction to Cocaine Prevented by Deleting Single Gene in Mouse BrainNEXT ARTICLE
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...
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