Novel RNA-based Vaccine Provides Protection Against Malaria

06:27 EDT 13 Jul 2018 | Genetic Engineering News

Generating vaccines toward eukaryotic pathogens has always presented challenges for researchers. While single-celled eukaryotic parasites, such as those that cause malaria may not seem close to humans evolutionarily, at the cellular level vaccine targets become limited due to homology with host molecules. However, now a team of investigators at Yale University has identified a novel target within the malaria parasite that protects against infection against the pathogen in mouse models—paving the way for the development of a human vaccine that works by targeting the specific protein that parasites use to evade the immune system.         Findings from the new study were published today in Nature Communications through an article titled “ Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection .” Malaria is the second leading cause of infectious disease worldwide and took close to a half-million lives in 2016. To date, no completely effective ...

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