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The virtuous self-tolerance of virtual memory T cells

03:46 EDT 14 Jul 2018 | Nature Publishing

"Virtual" memory CD8+ T cells are a subset of immune cells produced by homeostatic mechanisms involving response to self-antigens, raising the possibility that these cells could mediate autoimmunity. New work by Drobek et al demonstrates that virtual memory T cells are indeed favored by stronger T-cell receptor signals but exhibit minimal autoreactivity while maintaining self-tolerance.

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