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Assay for Arf GTP-binding Proteins

09:07 EDT 13 Sep 2018 | NIH

The National Cancer Institute's Laboratory of Cellular and Molecular Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize an antibody-based proteomics assay. 

The worldwide laboratory research reagents market is expected to surpass $13 billion in 2010, and the field of biotechnology appears key to maintaining the market's growth. Antibodies are becoming increasingly significant, especially for targeting the diseased cells and cell compounds.

Researchers at the National Cancer Institute (NCI), NIH, have developed an antibody-based assay that measures levels of Arf GTP-binding proteins, some of which have been linked to the invasive behavior of cancer cells. The assay is robust, can be performed both on cell lysates and fixed cells, and can distinguish among specific endogenous Arf-GTP isoforms.

IC: 
NCI
NIH Ref. No.: 
E-198-2010
Advantages: 
  • Ability to distinguish between the specific isoforms (i.e., Arf1, Arf3, Arf4, Arf5, and Arf6)
  •  Antibodies bind preferentially to the GTP-bound form of Arf
Applications: 
  • Research on Arf function in physiology and cancer
  • Research on cancer invasion
  • Research on membrane traffic and actin reorganization
Development Status: 

Discovery (Lead Identification)

Updated On: 
Jul 19, 2018
Provider Classifications: 
Publications: 
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NCI
Inventor Lab URL: 
https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology/paul-a-randazzo
LPM FIrst Name: 
John
LPM Last Name: 
Hewes
Inv Is lead: 
LPM Phone: 
240-276-5515
LPM Suffix: 
Ph.D.
LPM Organization: 
NCI - National Cancer Institute
DTDT Classification: 
Diagnostics
DTDT Description: 
Diagnostics
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/20394747
https://www.ncbi.nlm.nih.gov/pubmed/19262159
Publication Caption: 
PMID 20394747
PMID 19262159
Publication Title: 

Spang A, et al. Arf GAPs: gatekeepers of vesicle generation. 

Campa F, et al. Arf GTPase-activating proteins and their potential role in cell migration and invasion.

Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Licensing only

E Number Only: 
E-198-2010
Inventor First Name: 
Paul
Inventor Last Name: 
Randazzo

Original Article: Assay for Arf GTP-binding Proteins

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