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Fat Tissue Found to Be a Surprising Source of Diabetes

04:44 EDT 15 Oct 2018 | Genetic Engineering News

Scientists in Australia say their research points to fat tissue as a source of disease, and widens our understanding beyond the traditional focus on liver and pancreas as the main culprits. The study (“ Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance ”) appears in Cell Metabolism . “ Protein kinase C epsilon (PKC?) activation in the liver is proposed to inhibit insulin action through phosphorylation of the insulin receptor. Here, however, we demonstrated that global, but not liver-specific, deletion of PKC? in mice protected against diet-induced glucose intolerance and insulin resistance. Furthermore, PKC?-dependent alterations in insulin receptor phosphorylation were not detected. Adipose-tissue-specific knockout mice did exhibit improved glucose tolerance, but phosphoproteomics revealed no PKC?-dependent effect on the activation of insulin signaling pathways. Altered phosphorylation of adipocyte proteins associated with cell junctions and endosomes was associated with changes in hepatic expression of several ...

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