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Stoke Therapeutics and research collaborators from the University of Michigan will present new preclinical data supporting Stoke’s development of its antisense oligonucleotide technology to treat Dravet Syndrome at the annual meeting of the American Epilepsy Society in New Orleans.
Lori Isom, Ph.D., Maurice H. Seevers professor and chair of pharmacology at University of Michigan Medical School, will present the data at two poster sessions and one platform presentation, which will include a Q&A. Stoke’s executive team will also attend the conference.
The new data demonstrate the ways in which Stoke’s Targeted Augmentation of Nuclear Gene Output (TANGO) technology upregulates the Scn1a gene and restores physiologic levels of the NaV1.1 sodium ion channel protein to treat Dravet Syndrome, a rare and devastating form of epilepsy.
About Stoke Therapeutics
Launched in 2018, Stoke Therapeutics is a biotechnology company working to increase gene expression to treat a wide array of severe genetic diseases, including genetic conditions affecting the central nervous system, eye, liver and kidney. Stoke has raised $130 million in funding from two rounds of financing; investors include RTW Investments, RA Capital Management, Cormorant Asset Management, Perceptive Advisors, funds managed by Janus Henderson Investors, Redmile Group, Sphera Funds Management, and Alexandria Venture Investments, as well as founding investor Apple Tree Partners. For more information, visit www.stoketherapeutics.com and follow Stoke on Twitter @StokeTx.
Sara Green, Ten Bridge Communications
Most human diseases are caused by production of abnormal proteins or malfunctioning proteins. Antisense therapy involves inhibiting production of these proteins. When a gene is known to cause a specific disease and the genetic sequence ...
Epilepsy is defined as a disorder of brain function characterized by recurrent seizures that have a sudden onset. (Oxford Medical Dictionary). A seizure is caused by a sudden burst of excess electrical activity in the brain, causing a tempora...
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