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USP monograph modernization: Chemical medicines assay by potentiometric titration

04:18 EST 5 Dec 2018 | Lab Bulletin

USP and Metrohm jointly developed a potentiometric titration method for potassium bicarbonate and potassium carbonate assay. The new method uses autotitration combined with suitable equivalence point detection fulfilling all USP method validation requirements as per USP General Chapter <1225>. Many of the chemical medicine assay procedures are done by manual titration as per USP monographs. The manual titration procedure lacks data integrity and is prone to human error...

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Assays
An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity.  This can be a drug or biochemical substance or a cell in an organism or organic sample. ...