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Stoke Therapeutics will present on its pioneering work to develop the first gene-specific, disease-modifying therapies for genetic epilepsies at the 37th Annual J.P. Morgan Healthcare Conference in San Francisco next week.
Chief Executive Officer Ed Kaye, M.D., will share details on Stoke’s novel approach to upregulate gene expression with antisense oligonucleotide therapies. The technology, Targeted Augmentation of Nuclear Gene Output (TANGO), is designed to restore protein production to normal levels in patients with autosomal dominant disorders in which one copy of a gene is healthy and the other is dysfunctional.
Stoke’s lead indication is Dravet Syndrome, a rare and devastating form of genetic epilepsy that affects more than 35,000 patients in the U.S., the European Union and Japan. Dr. Kaye will present data showing that Stoke’s TANGO technology successfully increases production of the key protein missing in Dravet Syndrome, Nav1.1, in a highly precise, durable and controlled manner in mouse models. Stoke’s drug candidate would be the first therapy to address the root cause of Dravet Syndrome and modify the course of the disease.
Stoke is also advancing programs using TANGO in other disorders of the central nervous system as well as genetic diseases of the eye, liver and kidney.
Stoke’s presentation details:
Date: Tuesday, January 8, 2019
Time: 10 – 10:25 a.m. PST
Location: Westin St. Francis Hotel, Elizabethan Room D
About Stoke Therapeutics
Launched in 2018, Stoke Therapeutics is a biotechnology company working to increase gene expression to treat a wide array of severe genetic diseases, including genetic conditions affecting the central nervous system, eye, liver and kidney. Stoke has raised $130 million in funding from two rounds of financing; investors include Apple Tree Partners, RTW Investments, RA Capital Management, Cormorant Asset Management, Perceptive Advisors, funds managed by Janus Henderson Investors, Redmile Group, Sphera Funds Management, and Alexandria Venture Investments. For more information, visit www.StokeTherapeutics.com and follow Stoke on Twitter @StokeTx.
Ten Bridge Communications
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...
Health care (or healthcare) is the diagnosis, treatment, and prevention of disease, illness, injury, and other physical and mental impairments in humans. Health care is delivered by practitioners in medicine, chiropractic, dentistry, nursing, pharmacy, a...
The process of gene expression is used by eukaryotes, prokaryotes, and viruses to generate the macromolecular machinery for life. Steps in the gene expression process may be modulated, including the transcription, RNA splicing, translation, and post-tran...