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Regulation and activation of T lymphocytes depend on signalling by the T cell receptor (TCR) and also by co-signalling receptors that deliver negative or positive signals. The PD-1/PD-L1 signalling pathway is a negative regulatory mechanism that inhibits T cell proliferation and cytokine production. Blockade of the PD-1/PD-L1 interaction enhances anti-tumour immunity. The PD-1 pathway plays a major role in the inhibition of self-reactive T-cells.
AdipoGen’s PD-1/PD-L1 ELISA kits are sensitive and quantitative tools for the measurement of important immune checkpoint biomarkers. The PD-1 (human) ELISA kit detects soluble PD-1, a biomarker for immuno-oncology and autoimmune diseases. The PD-L1 (human) ELISA kit detects soluble PD-L1, a tumour biomarker for poor survival prognosis.
Original Article: AdipoGen PD-1/PD-L1 ELISA KitsNEXT ARTICLE
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Immunoassay - ELISA
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