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The Importance of the Mouse Genetic Background

11:50 EDT 26 Mar 2019 | Genetic Engineering News

Refreshing the genetic background After 5-10 generations of inbreeding, mouse colonies should be “refreshed”, to remove or prevent genetic drift accumulation in the colony. Several methods to refresh the genetic background may include the following: Backcross. Genetically Engineered Mutant Mouse (GEMM) strains may be backcrossed to the appropriate inbred or hybrid mouse strain purchased from […]

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