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One of the first questions we face when considering the therapeutic strategy for a patient with cancer is whether cure is possible. Stage is a key variable in the simple equation that summarises conventional thinking about solid cancers—metastatic equals incurable. Yet many patients with what is considered as curable cancer have occult metastases. Conversely, selected patients with metastatic cancer survive long-term after definitive therapy. Whether this observation represents a curative treatment outcome or simply good selection of patients with indolent cancer biology remains unknown.
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Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...