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Doxepin or diphenhydramine-lidocaine-antacid mouthwash modestly reduces radiation-related mucositis pain

12:44 EDT 17 Apr 2019 | 2 Minute Medicine

1. In this randomized controlled trial, the use of doxepin or diphenhydramine-lidocaine-antacid mouthwash reduced mucositis pain four hours after treatment but below the threshold for minimal clinically important difference. 2. Doxepin but not diphenhydramine-lidocaine-antacid mouthwash was associated with drowsiness, unpleasant taste, and higher frequency of stinging or burning than placebo. Evidence Rating Level: 1 (Excellent) […]
Source: 2 Minute Medicine

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