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The post-translational modification of proteins with linear ubiquitin (Ub) has previously been shown to be important for regulating inflammatory and immunological signaling in response to cellular pathogens. However, other functions of linear Ub are currently poorly defined. In this issue of The EMBO Journal, van Well and colleagues define a new role for linear Ub in regulating the intracellular stability and proteotoxicity of protein aggregates implicated in neurodegenerative diseases. This work provides new insights into the pathologic and potential therapeutic implications for linear Ub in the pathogenesis of these disorders.
Original Article: Lining up for quality control: linear ubiquitin and proteotoxicityNEXT ARTICLE
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...