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Lining up for quality control: linear ubiquitin and proteotoxicity

08:50 EDT 26 Apr 2019 | Nature Publishing

The post-translational modification of proteins with linear ubiquitin (Ub) has previously been shown to be important for regulating inflammatory and immunological signaling in response to cellular pathogens. However, other functions of linear Ub are currently poorly defined. In this issue of The EMBO Journal, van Well and colleagues define a new role for linear Ub in regulating the intracellular stability and proteotoxicity of protein aggregates implicated in neurodegenerative diseases. This work provides new insights into the pathologic and potential therapeutic implications for linear Ub in the pathogenesis of these disorders.

Original Article: Lining up for quality control: linear ubiquitin and proteotoxicity

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