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Extra-intestinal pathogenic Escherichia coli (ExPEC) are responsible for almost as many severe infections as pneumococci or meningococci. Estimates of E coli bacteraemia and sepsis in the health-care system in the USA suggest that more than 85 000 deaths are due to E coli sepsis.1 Additionally, multidrug resistance is an increasing problem, especially in E coli, and even more pronounced in severe infections, such as urosepsis.2 Alternative anti-infective strategies, such as a specific vaccine against ExPEC, would definitively increase the options for the treatment of invasive E coli disease and could be considered a great clinical advantage and contribute to decreasing antibiotic selection pressure.
Original Article: [Comment] A step further in a vaccine for Escherichia coliNEXT ARTICLE
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Sepsis, septicaemia and blood poisoning
Septicaemia (another name for blood poisoning) refers to a bacterial infection of the blood, whereas sepsis can also be caused by viral or fungal infections. Sepsis is not just limited to the blood and can affect the whole body, including the organ...