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Small Molecule Shows Marked Activity Against Ibrutinib-Resistant MCL

14:36 EDT 17 May 2019 | OncLive

Preclinical data suggest that the small molecule IACS-10759, which targets the oxidative phosphorylation (OXPHOS) and glutaminolysis pathways, may play a critical role in overcoming resistance to ibrutinib (Imbruvica) in mantle cell lymphoma.

Original Article: Small Molecule Shows Marked Activity Against Ibrutinib-Resistant MCL

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