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NIAID scientists develop 'mini-brain' model of human prion disease

20:00 EDT 13 Jun 2019 | AAAS

(NIH/National Institute of Allergy and Infectious Diseases) Scientists have used human skin cells to create what they believe is the first cerebral organoid system, or 'mini-brain,' for studying sporadic Creutzfeldt-Jakob disease (CJD). CJD is a fatal neurodegenerative brain disease of humans believed to be caused by infectious prion protein. The researchers, from NIH's National Institute of Allergy and Infectious Diseases, hope the human organoid model will enable them to evaluate potential CJD therapeutics and provide greater detail about human prion disease subtypes.

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