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The treatment of cancer using immunotherapies has garnered substantial attention and excitement following clinical benefit observed in patient populations previously refractory to treatment. New approaches continue to be developed to increase the subset of cancer patients responding to treatment – and to address the issue that highly personalized treatments may have manufacturing challenges. Furthermore, the field is open to new approaches with more promising toxicity profiles. This technology recognizes that the induction of anti-tumor T cell responses is a critical element in the development of effective immunotherapies against cancer.
This novel technology developed by researchers at the National Cancer Institute (NCI) is a cancer immunotherapy that harnesses the potent pre-existing cellular immunity against a commonly acquired virus, human cytomegalovirus (HCMV) that causes well controlled chronic infection in immunocompetent people. Using tumor tropic human papillomavirus pseudovirions, that contain plasmids expressing HCMV peptides or direct intra-tumoral injection of HCMV peptides, this methodology directs the pre-existing anti-HCMV immunity against those peptides to the tumors. In the presence of an immune response modifier, such as poly-IC, the anti-HCMV cellular immunity is re-directed to kill the cancerous tumors and induce antigen spreading to tumor-associated antigens.
The NCI seeks licensing and/or co-development of a cancer immunotherapy based on harnessing the pre-existing immune response to a chronic viral pathogen such as human cytomegalovirus (HCMV) to target solid tumors.
Pre-clinical (in vivo)
Licensing and research collaboration
Original Article: Cancer Immunotherapies That Harness Pre-Existing Antiviral ImmunityNEXT ARTICLE
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Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...