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[Comment] Lessons from an unsuccessful therapeutic trial

20:37 EDT 5 Jul 2019 | The Lancet

The development of a new medical treatment can be a herculean task. To be proven efficacious in a clinical trial, not only must a treatment effectively engage its target, but also investigators must choose the correct outcome as a metric of clinical effect, select an appropriate dose for testing, and enroll a suitable patient population, among many other important variables. Negative results are an important—albeit frustrating—step in the process of drug discovery.

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