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[Comment] Rimegepant oral disintegrating tablet for migraine

11:08 EDT 13 Jul 2019 | The Lancet

In The Lancet, Robert Croop and colleagues1 present a carefully designed phase 3 trial on an oral disintegrating tablet (ODT) of rimegepant for the acute treatment of migraine among 1375 patients (85% female, mean age 40·2 years [SD 12·0]). The trial was positive, showing an increase in relief from headache pain among the group receiving rimegepant at 2 h after dosing (10% over placebo) and improvement in the most bothersome symptoms, which included photophobia and nausea (8% over placebo). The onset was reported to be slightly faster than that of other gepants (first positive effect at 1 h for rimegepant vs 2 h for telcagepant) and the effect on the lower side (10% for rimegepant vs a mean of 17% in four trials on telcagepant), but the duration was up to 48 h.

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