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Fusion Glycoprotein Vaccine for Human Metapneumovirus

20:00 EDT 28 Oct 2018 | NIH

Human metapneumovirus (hMPV), a negative, single-stranded RNA virus, accounts for approximately 5-15% of infant respiratory tract infections and poses a severe risk of disease and hospitalization in both the elderly and the immunocompromised. Investigators at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID) have generated an hMPV fusion glycoprotein (“F protein”) stabilized in a prefusion conformation.

Stabilizing this prefusion conformation of the F protein reveals an immunodominant site which makes it an ideal vaccine immunogen. The prefusion stabilized F protein immunogen can be delivered as either an isolated homotrimer or trimers displayed on a nanoparticle. These immunogens elicit broad and potent hMPV-neutralizing antibodies.

This technology is available for licensing for commercial development in accordance with 35 U.S.C. § 209 and 37 CFR Part 404.

IC: 
NIAID
NIH Ref. No.: 
E-260-2014-0
Advantages: 
  • No human metapneumovirus vaccine is currently available
Applications: 
  • Vaccine for prevention of human metapneumovirus infection
Provider Technology ID: 
3342
Updated On: 
Oct 29, 2018
Date Published: 
Monday, October 29, 2018
Provider Classifications: 
Publications: 
Patent Application: 
62/096,744
PCT/IB2015/059991
15/539,640
15831073.0
Patent Authority: 
US
PCT
US
EP
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NIAID
NIAID
NIAID
NIAID
NIAID
NIAID
NIAID
Institute for Research in Biomedicine
Institute for Research in Biomedicine
Inventor Lab URL: 
https://irp.nih.gov/pi/peter-kwong
https://irp.nih.gov/pi/peter-collins
LPM FIrst Name: 
Vince
LPM Last Name: 
Contreras
LPM Address: 
5601 Fishers Lane, Suite 6D (MSC 9804)
LPM City: 
Rockville
LPM Zip: 
20892-9804
Inv Is lead: 
LPM State: 
MD
LPM Phone: 
240-669-2823
LPM Suffix: 
Ph.D.
LPM Organization: 
NIH Office of Technology Transfer
LPM Fax: 
240-627-3117
DTDT Classification: 
Viral
DTDT Description: 
Infectious Diseases - Vaccines - Viral
Pat Filing Date: 
2014-12-24
2015-12-24
2017-06-23
2015-12-24
Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
E Number Only: 
E-260-2014-0
Inventor First Name: 
Peter
Michael
Peter
Ursula
Guillaume
Baoshan
Yongping
Davide
Antonio
Inventor Last Name: 
Kwong
Joyce
Collins
Buchholz
Stewart-Jones
Zhang
Yang
Corti
Lanzavecchia

Original Article: Fusion Glycoprotein Vaccine for Human Metapneumovirus

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