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New clues as to why mutations in the MYH9 gene cause broad spectrum of disorders in humans

12:43 EDT 28 Oct 2019 | Science Daily

Researchers have used the Drosophila embryo to model human disease mutations that affect myosin motor activity. Through in vivo imaging and biophysical analysis, they demonstrated that engineering human MYH9-related disease mutations into Drosophila myosin II produces motors with altered organization and dynamics that fail to drive rapid cell movements, resulting in defects in epithelial morphogenesis.

Original Article: New clues as to why mutations in the MYH9 gene cause broad spectrum of disorders in humans

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