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CStone's PD-L1 Candidate Shows Positive Results for Lymphoma

00:22 EST 9 Nov 2019 | ChinaBio Today

Suzhou's CStone Pharma released positive results from a China Phase II trial of its PD-L1 candidate (CS1001) as a monotherapy in relapsed or refractory extranodal natural killer/T-cell lymphoma (rr-ENKTL). CS1001 produced an overall response rate of 41%, a complete and durable response rate of 32% and a benign safety profile. The company says studies have shown links between Epstein-Barr virus (EBV) infection and ENKTL. EBV infection induces immune tolerance by upgrading PD-L1 expression in tumor cells, promoting tumor growth. CStone is developing a pipeline of 15 oncology drug candidates. More details....

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