[Comment] International view on genetic frontotemporal dementia

21:08 EST 3 Dec 2019 | The Lancet

Frontotemporal dementia is a subtype of neurodegenerative dementia, characterised by progressive changes in behaviour and personality or language difficulties. Frontotemporal dementia has a strong genetic component,1 and microtubule-associated protein tau (MAPT), progranulin (GRN), and chromosome 9 open reading frame 72 (C9orf72) are the most common mutated genes. Patients with this condition show heterogeneity in clinical presentation and a wide variability in age at symptom onset, age at death, and disease duration.

Original Article: [Comment] International view on genetic frontotemporal dementia


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