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Research Presented Provides Further Insights into Amyloid and Tau Imaging Agents
BERLIN (PRWEB) January 15, 2020
Life Molecular Imaging (LMI) announces today that new research results on its approved and investigational positron emission tomography (PET) neuroimaging tracers will be presented at the 14th Human Amyloid Imaging (HAI) meeting in Miami (January 15-17, 2020). The contributions cover nine (9) presentations demonstrating the value of its approved compound Neuraceq™ (florbetaben F18 injection), and fifteen (15) presentations supporting the potential of its investigational Tau-PET tracer PI-2620.
A comprehensive clinical evaluation with imaging biomarkers, such as amyloid PET imaging, can improve the diagnostic accuracy. In addition, the combination of Neuraceq™ and the investigational PI-2620 tracer for the detection of tau pathology, provides a powerful PET imaging biomarker platform for the appropriate characterization of subjects enrolled in clinical trials supporting drug development in neurodegenerative diseases. The value of imaging biomarkers, particularly the combination of amyloid-beta and tau in the same subjects, is increasingly recognized. Highlights also include the presentation of the results from a multi-center evaluation of PI-2620 in subjects with progressive supranuclear palsy (PSP) as well as a poster describing the performance of PI-2620 in subjects with corticobasal syndrome (CBS).
"We are particullary impressed by the data that the research groups collected over the last year in PSP patients" said Dr. Andrew Stephens, MD, PhD, CMO of Life Molecular Imaging. "PI-2620's ability to also detect 4R tauopathies, such as PSP and CBS allows us to pursue the development of PI-2620 not only for AD, but also for additional neurodegenerative diseases, where previous tau tracers showed limitations."
Datasets involving LMI compounds presented at the HAI meeting include the following presentations:
Amyloid-PET Neuroimaging presentations involving Neuraceq (florbetaben F18 injection):
January 15, 2020
January 16, 2020
January 17, 2020
Tau-PET Neuroimaging presentations involving PI-2620:
January 15, 2020
January 16, 2020
January 17, 2020
About Neuraceq (florbetaben F18 injection)
Neuraceq™ (florbetaben F18 injection) is a radioactive diagnostic agent indicated for Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer’s Disease (AD) and other causes of cognitive decline.
A negative Neuraceq scan indicates sparse to no amyloid neuritic plaques and is inconsistent with a neuropathological diagnosis of AD at the time of image acquisition; a negative scan result reduces the likelihood that a patient’s cognitive impairment is due to AD. A positive Neuraceq scan indicates moderate to frequent amyloid neuritic plaques; neuropathological examination has shown this amount of amyloid neuritic plaque is present in patients with AD, but may also be present in patients with other types of neurologic conditions as well as older people with normal cognition.
Neuraceq™ is an adjunct to other diagnostic evaluations.
Limitations of Use
Important Safety Information
Risk for Image Interpretation and Other Errors
Neuraceq can be used to estimate the density of β-amyloid neuritic plaque deposition in the brain. Neuraceq is an adjunct to other diagnostic evaluations. Neuraceq images should be interpreted independent of a patient’s clinical information. Physicians should receive training prior to interpretation of Neuraceq images. Following training, image reading errors (especially false positives) may still occur. Additional interpretation errors may occur due to, but not limited to, motion artifacts or extensive brain atrophy.
Administration of Neuraceq, similar to other radiopharmaceuticals, contributes to a patient´s overall long-term cumulative radiation exposure. Long-term cumulative radiation exposure is associated with an increased risk of cancer. It is important to ensure safe handling to protect patients and health care workers from unintentional radiation exposure.
Most Common Adverse Reactions
In clinical trials, the most frequently observed adverse drug reactions in 872 subjects with 1090 Neuraceq™ administrations were injection/application site erythema (1.7%), injection site irritation (1.1%), and injection site pain (3.4%).
Tau deposits, in conjunction with beta-amyloid plaques, represent the other pathological hallmark of Alzheimer’s disease, with tau deposits further playing an important role in other neurodegenerative diseases. PI-2620 is binding to 3R/4R and 4R tau deposits and is a next generation 18F-labeled investigational PET tracer with favourable properties and imaging characteristics. It was discovered in a research collaboration between Life Molecular Imaging and AC Immune, a Swiss-based clinical stage biopharmaceutical company. Life Molecular Imaging has the exclusive, world-wide license for research, development and commercialization of tau PET tracers generated within the discovery program.
About Life Molecular Imaging (LMI)
Life Molecular Imaging (LMI, formerly Piramal Imaging) was formed in 2012 with the acquisition of the molecular imaging research and development portfolio of Bayer Pharma AG. It is now part of the Alliance Medical Group (a member of the Life Healthcare Group) offering an integrated business including research and development laboratories, a network of cyclotrons, radiopharmacies and imaging facilities. By developing novel PET tracers for molecular imaging, LMI is focusing on a key field of modern medicine. The organization strives to be a leader in the Molecular Imaging field by developing innovative products that improve early detection and characterization of chronic and life-threatening diseases, leading to better therapeutic outcomes and improved quality of life.
Please visit https://life-mi.com.
About Life Healthcare Group
Life Healthcare Group is a market-leading, international, diversified healthcare organization. Life Healthcare has over 33 years’ experience in the South African private healthcare sector, and currently operates 66 healthcare facilities in southern Africa. Services include acute hospital care, acute physical rehabilitation, acute mental healthcare, renal dialysis, and employee health and wellness services. The Group owns Alliance Medical Group, the leading independent provider of medical imaging services within Europe, operating across 10 international countries. Life Healthcare also owns Scanmed S.A. (Poland) which provides healthcare and medical services in 20 Polish cities, with over 65 medical specialisations and diagnostic services available in 32 facilities. Visit lifehealthcare.co.za
Nicole Fletcher | Marketing Communications | Life Molecular Imaging
+1 857-202-1122 | firstname.lastname@example.org
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