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(Goethe University Frankfurt) Whether a sick cell dies, divides, or travels through the body is regulated by a sophisticat-ed interplay of signal molecules and receptors on the cell membrane. One of the most im-portant molecular cues in the immune system is Tumour Necrosis Factor α (TNFα). Now, for the first time, researchers from Goethe University have visualised the molecular organ-isation of individual TNFα receptor molecules and the binding of TNFα to the cell mem-brane in cells using optical microscopy.
Original Article: Visualizing molecular patterns of membrane TNF receptorsNEXT ARTICLE
Cytokine Tumour Necrosis Factor (TNF)
TNF is a compound that is classified as a cytokine which plays a central role in the cellular mechanisms of apoptosis or cell death. However, there are a number of different kinds of TNF, just under twenty, but the family of molecules have very similar a...