ICR identifies key "microRNA" gene driving chemotherapy resistance in cancer

07:53 EST 12 Feb 2020 | Pharmafile

Researchers at the Institute of Cancer Research have discovered that a small RNA molecule known as microRNA gene MIR1249 contributes to the chemotherapy-resistant nature of some bile duct tumours, potentially paving the way for more effective cancer-fighting drugs.

The body’s WNT signalling network is partly responsible for the regulation of stem cells, but the MIR1249 gene is able, according to the researchers, to “rewire” this network, enabling cancer cells to co-opt the resilient, self-regenerating properties of stem cells, allowing them to survive bouts of chemotherapy.

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Original Article: ICR identifies key "microRNA" gene driving chemotherapy resistance in cancer


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