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Mechanism of controlling autophagy by liquid-liquid phase separation revealed

19:00 EST 12 Feb 2020 | AAAS

(Japan Science and Technology Agency) Japanese scientists elucidated characteristics of PAS through observing the Atg protein using a fluorescence microscope and successfully reconstituted PAS in vitro. The team revealed, for the first time, that PAS is in the state of liquid droplets formed by liquid-liquid phase separation of Atg13 together with other Atg proteins and that this liquid droplet is responsible for autophagy.

Original Article: Mechanism of controlling autophagy by liquid-liquid phase separation revealed

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