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Roscovitine enhances nuclear enrichment of traditionally cytoplasmic signaling molecules

14:23 EDT 26 Mar 2020 | News-Medical.net

Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear enrichment of certain traditionally cytoplasmic signaling molecules and enhanced differentiation and cell cycle arrest.

Original Article: Roscovitine enhances nuclear enrichment of traditionally cytoplasmic signaling molecules

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