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CRISPR-Cas9 Defies PAM Restrictions, Edits Genomic Regions Once Out of Bounds

20:00 EDT 26 Mar 2020 | Genetic Engineering News

Two new CRISPR-Cas9 variants, SpG and SpRY, enable unconstrained targeting across nearly the entire genome and with single base pair precision. SpG is capable of targeting an expanded set of NGN PAMs, and SpRY is hardly dependent at all on adjacent PAMs. The developers of SpRY report that it could be used to correct mutations associated with human diseases located in previously uneditable regions of the genome.

The post CRISPR-Cas9 Defies PAM Restrictions, Edits Genomic Regions Once Out of Bounds appeared first on GEN - Genetic Engineering and Biotechnology News.

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