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University of York uses G:BOX Imaging System As Cost-effective Method of Assessing Protein Expression

12:20 EDT 10 Aug 2010 | BioPortfolio

JUNE 1 2010 Cambridge, UK: Syngene, a world-leading manufacturer of image analysis solutions, is delighted to announce a G:BOX chemiluminescence imaging system is being used at the University of York as a fast, affordable method to determine expression of a wide range of proteins on chemiluminescent Western blots.

Scientists in the Technology Facility at the University of York are using a G:BOX chemiluminescence imaging system to image Western blots stained with alkaline phosphatase to screen new constructs for protein expression. This imaging ensures researchers in the facility can quickly demonstrate that recombinant clones are expressing the correct proteins and rapidly deliver them to other scientists for use in their studies.

Dr Jared Cartwright, a Laboratory Head in the Technology Facility explained: “We run a protein production service for researchers at York and other universities and to make this facility cost-efficient we have to use detection techniques with our Western blots which will identify the target proteins. Additionally, we have to analyse the results rapidly so using autoradiography was becoming too time consuming, expensive and presented issues with the incorporation of data in reports and publications.”

Dr Cartwright added: “To overcome these problems we assessed three different CCD imaging systems to determine which would best suit our range of applications. We found the G:BOX’s image capture and analysis software were simple to use and the quality of data was more precise than we previously obtained with autoradiography. As a result, we installed the system in 2008 and have been happy with its performance ever since.”

Laura Sullivan, Syngene’s Divisional Manager stated: “We are pleased our G:BOX chemiluminescence imager is helping a protein production facility to rapidly prove a diverse range of clones are producing the right proteins. The work at the University of York shows how flexible a G:BOX chemiluminescence image analyser is, making this system ideal for any laboratory where running efficiently and cost-effectively are critical.”

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For Further Information Contact:

Jayne Arthur, Syngene, Beacon House, Nuffield Road, Cambridge, CB4 1TF, UK.

Tel: +44(0) 1223-727123 Fax +44 (0) 1223-727101

Email: jayne.arthur@syngene.com Web site: www.syngene.com

Dr Jared Cartwright, Technology Facility, Department of Biology (Area 15) University of York, PO Box 373, York YO10 5YW, UK.

Tel: +44(0) 1904 328797 Fax: +44(0) 1904 328804

Email: jc46@york.ac.uk Web site: www.york.ac.uk

Editor Contact:

Dr Sue Pearson, International Science Writer, PO Box 170, Hitchin, Hertfordshire SG5 3GD, UK.

Tel/Fax + 44(0) 1462-635327 Email: sue6.pearson@ntlworld.com
Note to Editors

About Syngene

Syngene is a world-leading supplier of integrated imaging solutions for analysis and documentation of gel-based information. Syngene’s systems are used by more than 10,000 research organisations and over 50,000 individual scientists world-wide and include many of the world’s top pharmaceutical companies and major research institutes.

Syngene, founded in 1997 is a division of the Cambridge based Synoptics Group. The Group’s other divisions, Syncroscopy and Synbiosis, specialise in digital imaging solutions for microscopy and microbial applications respectively. Synoptics currently employs over 40 people in its UK and subsidiary operation in Frederick, USA.

About the Technology Facility

The Technology Facility at the University of York’s remit is to provide access to technology and research services for the biosciences. It provides a unique facility that allows ready access to a wide range of technologies and expertise in an integrated manner that can help drive forward research efficiently and cost effectively. Clients include research groups from within the University, many external universities throughout the world, and an array of commercial enterprises of all sizes.

The Technology Facility offers state-of-the-art equipment and within this facility, the Protein Production facility consists of nine specialised areas including two tissue culture suites, two growth and fermentation rooms, two wet lab areas, a core facility of cold and centrifugation rooms and a protein purification suite. The laboratories provide a complete service or selected specialised steps involved in the production of recombinant proteins. In addition to the wide range of high quality instrumentation incorporated in the facility, there are highly trained staff members who are responsible for the management of the laboratory and provision of technical assistance.

For Further Information Contact: Jayne Arthur, Syngene, Beacon House, Nuffield Road, Cambridge, CB4 1TF, UK. Tel: +44(0) 1223-727123 Fax +44 (0) 1223-727101 Email: jayne.arthur@syngene.com Web site: www.syngene.com NEXT ARTICLE

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