Nutrition Research

18:05 EDT 22nd July 2018 | BioPortfolio

The Effect of Dextran Sulfate-as Model Glycosaminoglycan Analogue-on Membrane Lipids: DPPC, Cholesterol, and DPPC-Cholesterol Mixture. The Monolayer Study.

Glycosaminoglycans (GAGs) are essential components of the extracellular matrices (ECMs) located on the outer surface of cellular membranes. They belong to the group of polysaccharides involved in diverse biological processes acting on the surface and across natural lipid membranes. Recently, particular attention has been focused on possible role of GAGs in the amyloid deposits. The amyloid formati...

Hazelnut and cocoa spread improves flow-mediated dilatation in smokers.

Hazelnut and cocoa spread is an Italian product containing cocoa and hazelnut. Several epidemiological studies suggest that cocoa and hazelnuts cocoa exert beneficial cardiovascular effects. To investigate whether in smokers, hazelnut and cocoa spread elicits artery dilatation via down-regulation of oxidative stress. Flow-mediated dilatation (FMD), oxidative stress (as assessed by serum isoprostan...

Perioperative enteral supplementation with glutamine, fiber, and oligosaccharide reduces early postoperative surgical stress following esophagectomy for esophageal cancer.

We clarified the effects of perioperative enteral supplementation with glutamine, fiber, and oligosaccharide (GFO) after an esophagectomy on preventing surgical stress.

Disease Gene Classification with Metagraph Representations.

This chapter is based on exploiting the network-based representations of proteins, metagraphs, in protein-protein interaction network to identify candidate disease-causing proteins. Protein-protein interaction (PPI) networks are effective tools in studying the functional roles of proteins in the development of various diseases. However, they are insufficient without the support of additional biolo...

Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics.

Current estimates report that approximately 25% of U.S. adults use dietary supplements for medicinal purposes. Yet, regulation and transparency within the dietary supplement industry remains a challenge, and economic incentives encourage adulteration or augmentation of botanical dietary supplement products. Undisclosed changes to the dietary supplement composition could impact safety and efficacy;...

Pyridoxal kinase: A vitamin B6 salvage pathway enzyme from Leishmania donovani.

Pyridoxal kinase (PdxK, EC is an important enzyme of vitamin B6 salvage pathway which is required for phosphorylation of B6 vitamers. In the present study, pyridoxal kinase (pdxK) gene from Leishmania donovani (LdPdxK) was cloned and a 33 kDa protein was expressed and kinetically characterized. Site-directed mutagenesis was performed to determine the functional significance of conserve...

Agarose‑silver particles films: Effect of calcium ascorbate in nanoparticles synthesis and film properties.

New nanoparticles containing biomaterials are emerging as versatile active platforms in a great number of applications, for example, as skin substitutes and therapeutic media. The present study describes the preparation of silver nanoparticles (AgNPs) embedded in agarose films and the impact of calcium ascorbate in the formation of ANPs as well as in the final properties of the films. Colloidal Ag...

Neuroprotective effects of cordycepin inhibit Aβ-induced apoptosis in hippocampal neurons.

In Alzheimer's disease (AD), β-amyloid (Aβ) protein toxicity increases the formation of reactive oxygen species (ROS) and intracellular calcium levels, resulting in neuronal dysfunction, neurodegenerative disorders, and cell death. Cordycepin is a derivative of the nucleoside adenosine; also, it is speculated to exert neuroprotective effects against Aβ-induced oxidative toxicity in hippocampal ...

Review of potential health risks associated with nanoscopic calcium phosphate.

Calcium phosphate is applied in many products in biomedicine, but also in toothpastes and cosmetics. In some cases, it is present in nanoparticulate form, either on purpose or after degradation or mechanical abrasion. Possible concerns are related to the biological effect of such nanoparticles. A thorough literature review shows that calcium phosphate nanoparticles as such have no inherent toxicit...

Environmental factors, gut microbiota, and colorectal cancer prevention.

The substantial burden of colorectal cancer and increasing trend in young adults highlight the importance of lifestyle modification as a complement to screening for colorectal cancer prevention. Several dietary and lifestyle factors have been implicated in the development of colorectal cancer, possibly through the intricate metabolic and inflammatory mechanisms. Likewise, as a key metabolic and im...

Protein-protein interactions of human viruses.

Viruses infect their human hosts by a series of interactions between viral and host proteins, indicating that detailed knowledge of such virus-host interaction interfaces are critical for our understanding of viral infection mechanisms, disease etiology and the development of new drugs. In this review, we primarily survey human host-virus interaction data that are available from public databases f...

Cardiomyocyte-specific knockout of endothelin receptor a attenuates obesity cardiomyopathy.

Endothelin (ET)-1 is implicated in the pathophysiology of cardiovascular diseases although its role in obesity anomalies has not been fully elucidated. This study was designed to examine the impact of ET-1 receptor A (ET) ablation on obesity-induced changes in cardiac geometry and contractile function, as well as the mechanisms involved with a focus on autophagy. Cardiomyocyte-specific ET receptor...

Preparation of positively charged composite nanofiltration membranes by quaternization crosslinking for precise molecular and ionic separations.

Developing nanofiltration (NF) membranes with highly efficient and precise separation ability is of great significance for the molecular and ionic separations. In this work, positively charged composite NF membranes were engineered via soaking of polysulfone (PSF) ultrafiltration membranes in poly(N-vinyl imidazole) (PVI) solutions followed by a quaternization crosslinking step. The PVI was firmly...

Polytetrafluoroethylene (PTFE) hollow fiber AnMBR performance in the treatment of organic wastewater with varying salinity and membrane cleaning behavior.

PTFE hollow fiber anaerobic membrane bio-reactor (AnMBR) performance was investigated in the treatment of organic wastewater, with varying salinity and PTFE membrane cleaning behavior. The AnMBR was operated for 226 days, with a total and biological COD removal efficiency of 97.2% and 89.9% respectively, at a NaCl concentration of 35 g L. A high number of Proteobacteria (38.2%) and Bacteroid...

Upgrading methane fermentation of food waste by using a hollow fiber type anaerobic membrane bioreactor.

In this study, the effects of organic loading rates (OLRs) on anaerobic fermentation of food waste were comprehensively evaluated using a hollow fiber type anaerobic membrane bioreactor (HF-AnMBR). Compared to other OLRs, biogas production rate was highest at the OLR of 9.72 g-COD/L/d, the organic matter removal efficiency was also significantly higher and VFA was in lower concentration. COD con...

A murine model of wheat versus potato allergy: Patatin and 53kDa protein are the potential allergen from potato.

Wheat allergy is the most common around the world as gluten is the potential allergen. People diagnosed with wheat allergy were mainly substitute with other novel food such as potato though it is also being reported for allergenic manifestations. Thus there is an increasing demand for developing a BALB/c mice model to empathize the allergic properties of potato protein and its fractions. Purified ...

Marine ω-3, vitamin D levels, disease outcome and periodontal status in rheumatoid arthritis outpatients.

Marine ω-3 fatty acids (FAs) and Vitamin D (VitD) are reportedly capable of down-regulating inflammation in rheumatoid arthritis (RA) and periodontal disease. This study was undertaken to relate marine FA and VitD status to RA disease status and periodontal conditions.

Custom-built electrostatics and supplementary bonding in the design of reinforced Collagen-g-P(methyl methacrylate-co-ethyl acrylate)/ nylon 66 core-shell fibers.

In this study, Acid Soluble Collagen-g-P(methyl methacrylate-co-ethyl acrylate) (CME) was synthesized to take advantage of the flexibility of the resulted branched polymer chains and the high density of their chain entanglement. The coaxial electrospinning technique was applied to study the effect of electrically and structurally varied materials on fiber formation and fiber morphology when CME an...

Vitamin D level and endothelial dysfunction.

Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo: A meta-analysis.

To explore the relationship among the vitamin D receptor (VDR) gene polymorphisms, serum 25-hydroxyvitamin D levels, and vitiligo.

Prognostic role of chromodomain helicase DNA binding protein 1-like protein in human solid cancers: A meta-analysis.

Chromodomain helicase DNA binding protein 1-like (CHD1L) played vital roles in tumorigenesis and development. Its aberrant expression was reported to be related to progression and prognosis in various tumors. However, no consensus on the prognostic value of CHD1L protein has been made. This meta-analysis was aimed to assess the clinical significance of CHD1L protein in human solid tumors.

Low-dose vitamin A therapy on T lymphocyte function in neonatal pneumonia.

We aimed at studying the effect of adjuvant therapy with low-dose vitamin A on the function of T lymphocytes in neonatal pneumonia.

Scurvy as cause of purpura in the XXI century: a review on this "ancient" disease.

Scurvy is defined as a deficiency of ascorbic acid, which is an essential exogenous vitamin in humans. Vitamin C is involved in collagen synthesis and its deficit can cause disorders of connective tissue. The most frequent symptoms are weakness, arthralgias, anorexia and depression, commonly associated with follicular hyperkeratosis and perifollicular hemorrhage, with purpura.

Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia.

Children with acute pneumonia may be vitamin D deficient. Clinical trials have found that prophylactic vitamin D supplementation decreases the risk of developing pneumonia in children. Data on the therapeutic effects of vitamin D in acute childhood pneumonia are limited.

Dietary proteins improve hibernation and subsequent reproduction in the European hamster, Cricetus cricetus.

The reproductive success of hibernators depends not only on food quality during reproduction, but also on their body condition when emerging after hibernation, which in turn is highly dependent on the hibernation pattern. To date, no studies have fully investigated the role of macronutrients throughout the annual lifecycle of hibernators and the strong interdependency between its different phases....

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