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Ophthalmology Research

11:24 EDT 15th August 2018 | BioPortfolio

Progression of subclinical atherosclerosis in systemic lupus erythematosus versus rheumatoid arthritis: the impact of low disease activity.

The progression of subclinical atherosclerosis in SLE and RA has not been comparatively assessed. We sought to investigate the impact of low disease activity and other disease-related factors on atherosclerosis progression in SLE vs RA.

First Report of Ligustrum Virus A on Syringa reticulata var. mandshurica (Oleaceae) with a New Yellow Vein and Malformed Needle-Shaped Leaf Disease in China.

Searching for Pediatric Legionnaire Disease in a Population With High Adult Incidence.

Hepatitis C virus manipulates humans as its favorite host for long term relationship.

Chronic hepatitis C virus (HCV) infection associated liver disease is a global health problem. HCV often causes silent disease, and eventually progresses to end stage liver disease. HCV infects hepatocytes, however initial manifestation of liver disease is mostly displayed in hepatic stellate cells causing fibrosis/cirrhosis, and believed to be occurring from inflammation in the liver. It is still...

Kidney transplant recipients with polycystic kidney disease have a lower risk of post-transplant BK infection than those with end-stage renal disease due to other causes.

Polyomavirus-associated nephropathy is associated with high risk of kidney allograft loss. Whether the cause of native end-stage renal disease influences the risk of BK infection is unclear.

Retinal vascular density in multiple sclerosis: a one year follow up.

Vascular pathology is increasingly acknowledged as a risk factor of multiple sclerosis (MS). Vascular density (VD) is reduced in MS patients' eyes on optical coherence tomography (OCT) angiography (A).

A systems-based model of Alzheimer's disease.

The new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease has been developed to accelerate drug discovery and offer a common structure and language to construct new Alzheimer's disease conceptual models. However, as a "complex" disease, a model based on systems-level understanding is needed to accommodate the complex, interacting etiologic pathw...

Liver disease in systemic Lupus erythematodes - results of an explorative observational study.

 Systemic lupus erythematodes (SLE) represents an autoimmune disease with a highly variable clinical course affecting numerous organs. Hepatic manifestation seems to be rare. It is not clear whether hepatic disease in SLE is of any prognostic importance or whether it correlates with disease activity.

Genomic Screening of Fabry Disease in Young Stroke Patients: the Taiwan Experience and a Review of the Literature.

Fabry disease is a X-linked disease, and enzyme-based screening methods are not suitable for female patients.

Design considerations for the enhancement of human color vision by breaking binocular redundancy.

To see color, the human visual system combines the response of three types of cone cells in the retina-a compressive process that discards a significant amount of spectral information. Here, we present designs based on thin-film optical filters with the goal of enhancing human color vision by breaking its inherent binocular redundancy, providing different spectral content to each eye. We fabricate...

Temperature-dependent excitonic superuid plasma frequency evolution in an excitonic insulator, TaNiSe.

An interesting van der Waals material, TaNiSe has been known one of strong excitonic insulator candidates since it has very small or zero bandgap and can have a strong exciton binding energy because of its quasi-one-dimensional crystal structure. Here we investigate a single crystal TaNiSe using optical spectroscopy. TaNiSe has quasi-one-dimensional chains along the a-axis. We have obtained anisot...

Optical coherence tomography retinal ganglion cell complex analysis for the detection of early chiasmal compression.

To report patients with sellar tumors and chiasmal compression with normal visual fields, who demonstrate damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) on optical coherence tomography (OCT).

Classification and treatment of orbital venous malformations: an updated review.

Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angiogenesis, hemodynamics, and locations. Management of OVM is complicated and challeng...

Vision Impairment and Risk of Dementia: Findings from the English Longitudinal Study of Ageing.

To determine whether vision impairment is independently associated cross-sectionally and longitudinally with dementia.

Optical windows for head tissues in near and short-wave infrared regions: approaching transcranial light applications.

Optical properties of the rat head tissues (brain cortex, cranial bone and scalp skin) are assessed, aiming at transcranial light applications such as optical imaging and phototherapy. The spectral measurements are carried out over the wide spectral range of 350-2800 nm, involving visible, near-infrared (NIR) and short-wave infrared (SWIR) regions. Four tissue transparency windows are considered: ...

Spectral correction for handheld optoacoustic imaging by means of near-infrared optical tomography in reflection mode.

In vivo imaging of tissue/vasculature oxygen saturation levels is of prime interest in many clinical applications. To this end, the feasibility of combining two distinct and complementary imaging modalities is investigated: optoacoustics (OA) and near-infrared optical tomography (NIROT), both operating non-invasively in reflection mode. Experiments were conducted on two optically heterogeneous pha...

Acute Vision Loss From Dacryocystitis.

Utility of Optical Coherence Tomography for Guiding Laser Therapy Among Patients With Recurrent Respiratory Papillomatosis.

Recurrent respiratory papillomatosis (RRP) is a viral-induced disease caused by human papillomavirus and the second leading cause of dysphonia in children; however, neither a cure nor a definitive surgical treatment is currently available for RRP. Although laser therapy is often used in the treatment of RRP, the lack of real-time laser-tissue interaction feedback undermines the ability of physicia...

Association of Fellow Eye With Study Eye Disease Trajectories and Need for Fellow Eye Treatment in Collaborative Initial Glaucoma Treatment Study (CIGTS) Participants.

Clinicians would benefit from knowing the association of glaucomatous change in 2 eyes of the same patient.

Swept-Source Optical Coherence Tomography Angiography of Microaneurysms in Myopic Retinoschisis.

Punctate Retinal Pigment Epitheliopathy and Choroidopathy After Radiotherapy With Chemotherapy.

Visualization of Capillary Dropout Emanating From an Optic Disc Pit Using Optical Coherence Tomography Angiography.

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging.

Drug delivery by intravitreal injection remains problematic, small agents and macromolecules both clearing rapidly. Typical carriers use microparticles (>2 μm), with size-related liabilities, to slow diffusion. We recently described cationic nanoparticles (NP) where conjugated Arg peptides prolonged residence in rat eyes, through ionic interaction with vitreal poly-anions. Here we extended this s...

MicroRNA-124 Dysregulation is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina.

We sought to determine the role and retinal cellular location of microRNA-124 (miR-124) in a neuroinflammatory model of retinal degeneration. Further, we explored the anti-inflammatory relationship of miR-124 with a predicted messenger RNA (mRNA) binding partner, chemokine (C-C motif) ligand 2 (Ccl2), which is crucially involved in inflammatory cell recruitment in the damaged retina.

Retinal Microvascular Impairment in the Early Stages of Parkinson's Disease.

To detect the retinal microvascular impairment using optical coherence tomography angiography (OCT-A) in patients with Parkinson's disease (PD) and find a correlation between the microvascular impairment and the neuronal damage.

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